Resistance to activated protein C and factor V Leiden
نویسندگان
چکیده
منابع مشابه
Resistance to activated protein C and factor V Leiden.
Over the last four years, there has been an explosion of knowledge about APCr and factor V Leiden. However, there remain a considerable number of difficult clinical areas in which there are no clear answers. Undoubtedly, factor V Leiden is commonly found in association with venous thromboembolic disease in whatever manifestation, but equally it has an unusually high frequency in the general pop...
متن کاملActivated protein C resistance and factor V Leiden: a review.
CONTEXT Factor V Leiden (FVL) is the most common heritable cause of venous thrombosis. It is caused by a single nucleotide substitution resulting in an R506Q missense mutation, resulting in factor V resistance to activated protein C (APC) inactivation. Carriers of FVL have an increased susceptibility to venous thrombosis, which is further increased in the presence of other genetic or environmen...
متن کاملEpidemiology of Activated Protein C Resistance and Factor V Leiden Mutation in the Mediterranean Region
Venous thromboembolic disorders (VTE) are serious disorders with high morbidity and mortality rates. Many genetic and acquired risk factors were identified to cause VTE. The most common genetic risk factor is Factor V Leiden mutation (FVL). FVL was found in high percentage of populations of Caucasian origin but was almost absent in non-Caucasians. It was also reported in populations living in N...
متن کاملActivated protein C resistance, factor V Leiden, and central retinal vein occlusion in young adults.
OBJECTIVE To confirm the relationship between resistance to activated protein C (APC), factor V Leiden, and central retinal vein occlusion in young adults as reported in a recent study of patients younger than 50 years. PATIENTS AND METHODS Patients younger than 50 years with central retinal vein occlusion were identified from the medical records of the Wills Eye Hospital Retina and Retina Va...
متن کاملActivated protein C resistance -- in the absence of factor V Leiden -- and pregnancy.
BACKGROUND Activated protein C (APC) resistance with or without factor V Leiden (FVL) is a major risk factor for venous thromboembolism. Many previous pregnancy studies have been focused on APC resistance caused by FVL. Very few have investigated APC resistance in the absence of FVL (APCR(FVL-)). MATERIAL AND METHODS In a prospective study of 2480 unselected gravidae, blood was drawn in early...
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ژورنال
عنوان ژورنال: QJM
سال: 1997
ISSN: 1460-2393
DOI: 10.1093/qjmed/90.6.379